The steroid receptor RNA activator is the first functional RNA encoding a protein - Université Denis Diderot - Paris VII Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 2004

The steroid receptor RNA activator is the first functional RNA encoding a protein

S. Chooniedass-Kothari
  • Fonction : Auteur
E. Emberley
  • Fonction : Auteur
M.K. K Hamedani
  • Fonction : Auteur
S. Troup
  • Fonction : Auteur
A. Czosnek
  • Fonction : Auteur
M. Mutawe
  • Fonction : Auteur
P.H. H Watson
  • Fonction : Auteur
E. Leygue
  • Fonction : Auteur

Résumé

The steroid receptor RNA activator (SRA) has previously been characterized as belonging to the growing family of functional non-coding RNAs. However, we recently reported the Western blot detection of a putative endogenous SRA protein (SRAP) in breast cancer cells. Herein, we successfully suppressed the expression of this protein through specific RNA interference assay, unequivocally confirming its existence. Moreover, using database searches and Western blot analysis, we also showed that SRAP is highly conserved among chordata. Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein.

Dates et versions

hal-02127389 , version 1 (21-05-2019)

Identifiants

Citer

S. Chooniedass-Kothari, E. Emberley, M.K. K Hamedani, S. Troup, X. Wang, et al.. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Letters, 2004, 566 (1-3), pp.43-47. ⟨10.1016/j.febslet.2004.03.104⟩. ⟨hal-02127389⟩

Collections

UNIV-PARIS7
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More