The steroid receptor RNA activator is the first functional RNA encoding a protein

Abstract : The steroid receptor RNA activator (SRA) has previously been characterized as belonging to the growing family of functional non-coding RNAs. However, we recently reported the Western blot detection of a putative endogenous SRA protein (SRAP) in breast cancer cells. Herein, we successfully suppressed the expression of this protein through specific RNA interference assay, unequivocally confirming its existence. Moreover, using database searches and Western blot analysis, we also showed that SRAP is highly conserved among chordata. Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein.
Document type :
Journal articles
Complete list of metadatas

Cited literature [13 references]  Display  Hide  Download

https://hal-univ-diderot.archives-ouvertes.fr/hal-02127389
Contributor : Florent Hube <>
Submitted on : Tuesday, May 21, 2019 - 1:50:56 PM
Last modification on : Wednesday, May 29, 2019 - 1:22:19 AM

Links full text

Identifiers

Collections

Citation

S. Chooniedass-Kothari, E. Emberley, M.K. Hamedani, S. Troup, X. Wang, et al.. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Letters, Wiley, 2004, 566 (1-3), pp.43-47. ⟨10.1016/j.febslet.2004.03.104⟩. ⟨hal-02127389⟩

Share

Metrics

Record views

8